From A as in “astaxanthin” to Z as in “zinc”… It seems, there’s a supplement for everything. Everything but active tissue repair. Yes, a healthy diet, anti-inflammatory vitamins and related compounds may help you recover from the majority of life’s collateral damage. Ranging from the inevitable daily wear and tear of our stressful lives to a debilitating injury. Life is a full contact sport no one makes it out without at least few bumps and bruises. But nothing like BPC-157, being unregulated and widely available. BPC-157 has actively promoted wound, bone and overall tissue healing. Unheard of, Until now…
BPC-157 is a naturally occurring anti-ulcer agent
Initially described in the early 1990 (Sikiric 1993), Pentadecapeptide BPC 157 has been identified as an endogenous antiulcer peptidergic agent – in other words: BPC-157 is small peptide (only 15 amino acids) that occurs naturally in our gastric juice, where its main function seems to be to kickstart and accelerate the renewal and repair of the constantly assaulted lining of our intestinal tract.
When looking at the mechanisms involved, BPC-157 works by encouraging crucial growth factors and enhancing the nitric oxide pathway – it is thus not the simply vascular endothelial growth factor (VEGF)* analog it is often misrepresented as. Rather than acting like VEGF it will promote the complex physiological processes that occur during wound healing and tissue regeneration and repair -both inside and outside of the gastrointestinal tract.
*Vascular endothelial growth factor (VEGF), is a protein produced by cells that stimulates the formation of blood vessels.
VEGF and related growth factors as they are promoted by BPC-157 has been shown to …
- promote the regeneration of the cells of the intestinal wall (intestinal health | Sikiric 2018)
- promote and accelerate muscle, tendon and bone healing (sports and other tissue and bone injuries | Brcic 2009, Krivic 2008, Sebecic 1999)
- trigger the repair and replacement of atherosclerotic endothelial cells (cardiovascular health | Sikiric 2018)
- promote, optimize and accelerate wound healing (skin health and organ damage | Huang 2015; Stupnisek 2015)
- prevent and reverse lesions of the intestinal tract, liver, and even brain as they can occur in response to the (ab-)use of certain pain medications (general organ health | Drmic 2018) and the cardiovascular side effects of anti-psychotics (heart health | Strinic 2017)
- heal (stress-induced) ulcers and fistulas as they are increasingly common due to our stressful (this refers to “stress” as general oxidative stress) lifestyles (GI health and beyond | Szabo 2017; Grgic 2016)
- serve as a remedy for a plethora of central nervous system disorders that originate in the gut by (a) the local repair of the intestinal lining and (b) direct neuroprotective effects in the brain (brain & CNS health | Sikiric 2016)
The Body Protecting Compound
No wonder Sikiric et al. decided to call the protein they discovered in the early 90s a “B.P.C.”, i.e. a “Body Protecting Compound”, a compound that is attracting significant attention mainly within the athletic community – but its powerful healing properties are spreading due to the fact that its ability to battle muscular (Brcic 2009)or tendon injuries (cf. Krivic 2008) are one of many health benefits of BPC. For people with Crohn’s disease, IBS and other intestinal pathologies, for example, BPC-157 could literally be a life-saver. Even just the health conscious, BPC-157 could act as s potentially health-promoting health-insurance, which acts on signaling pathways that have been implicated in heart and vascular health (Wada 2017)and seem to play a role in the etiology* of vascular dementia, Alzheimer’s (Mateo2007; Garcia2014) and general organ health.
*the cause, set of causes, or manner of causation of a disease or condition.
“a disease of unknown etiology”5>
Optimized Healing Agent
When looking at the facts, it must be noted that VEGF shares one important quality with better known growth factors like IGF1: in some unfortunate contexts, they entail the risk of stimulating growth where you don’t want it. Indiscriminately injecting copious amounts of straight VEGF is thus not not recommended. Using BPC-157 to promote its natural production, on the other hand, is a much safer option – an option with a plethora of potential health benefits (see illustration):
Something for Everyone
Despite the lack of quality randomized controlled studies, the complex health benefits that have been associated with BPC-157 directly or one or several of the growth factors that are released in response to its use. The popularity and what data we do have clearly suggest that the often-heard recommendation to use BPC-157 for acute injury treatment is not a bad idea. But it does not take advantage of the full regenerative potential of this unique peptide. Figuratively speaking, BPC-157 has the potential to be way more than an airbag, of which you’d want that it remains in its casing waiting for the one moment to save your life. Used continuously it could act pretty much like an advanced driver assistance system that initiates an emergency stop and/or evades collisions and hence renders the use of an airbag redundant.
BPC-167 longevity (Immortal stack)
- TB-500, become near untikkillabke like s terminator (Getting the muscles is another article”)
Dosing and administration
BPC-157 does not share two central limitations that complicate the use of other secretagogues for medical purposes: BPC-157 is orally bioavailable (Sikiric 2018) and effective even at relatively low concentrations.
For example, a 2009 study by Brcic etal. that was published in the Journal of Physiological Pharmacology, found a profound acceleration of the healing process of crushed muscles and transected muscle and tendons in rodents that received as little as 10 µg of BPC-157 – an amount that translates to only 5.4 µg of BPC-157 per kg body mass in humans.
*a substance that promotes secretion or releasing of another substance .5>
Brcic’s study is not the only one in which scientists recorded impressive tissue healing in response to the “oral” administration of BPC-157. The problem, however, is that each of these studies simulated the oral administration of the agent by injecting the peptide into the peritoneum (body cavity).Why’s that a problem? Well, while it is unquestionably a more convenient and reliable alternative to regular means of oral drug administration, we cannot say for sure if the injection into the intraperitoneal cavity affects the bioavailability and pharmacology of BPC-157 differently than washing it down with water and/or even food.
BPC is Usually taken Like this
Usually mixed with bacteriostatic and injected subcutaneously. Most of information on BPC-157 and it has been shown to be effective when injected once a day in the range of 1-10mcg per kg of body weight. In most instances, this equals a dose of 200mcg up to 800mcg. Some researchers achieve the most effective results dosing twice per day with 250-350mcg for a total of 500-700mcg per day.
Purity and Fakes
The biggest issue with peptides is their costly manufacture and tendencies to be sold as fake . Ask the supplier for the lab reports and not the chinese ones. When we secure s quality peptide company we will let out members know!